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KMID : 0358120020280010031
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Journal of the Korean Public Health Association
2002 Volume.28 No. 1 p.31 ~ p.38
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A Study on the Difference of Blood Biochemical Component Levels in Alcoholics, Moderate Drinkers, and Normal Non-drinkers
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Lee Sung-Lim
Kim Jong-Gyu
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Abstract
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This study was performed to investigate the effects of alcohol consumption on blood components. This was a double-blind, cross-sectional, observational study of alcoholics, an alcoholic control group (moderate drinkers), and a non-alcoholic control group (normal non-drinkers). The participating subjects were a total of 102 Korean male adults, 34-64 years of age, consisting of 34 men who visited a clinic for alcoholics in a university hospital and as a result were hospitalized for more than 1 day (alcoholics group), 34 normal functioning men who drink alcohol more than two times per week (moderate drinkers), and 34 age-matched men who drink alcohol less than once per month or never (normal non-drinkers). Fasting blood samples from the subjects were analyzed by a biochemical analyzer. Six blood components were compared among the three groups. In the alcoholics group twenty-one components were compared between when they were hospitalized and when they were discharged. The alcoholics group showed significantly lower hemoglobin and total cholesterol levels (p<0.05) and higher glucose, aspartate aminotransferase (AST), alanino aminotransferase (ALT) and gamma-glutamil transpeptidase (v-GTP) levels (p<0.0l) compared with the moderate drinkers and the normal non-drinkers. The only significant difference between the moderate drinkers and the normal non-drinkers was the glucose level. Among the twenty one components in the alcoholics group, bilirubin, direct; biirubin, total; Ca; total protein; and total cholesterol were significantly different when they were hospitalized and when they were discharged (p<0.05). Hemoglobin, AST, ALT, and v-GPT levels were improved when the alcoholics were discharged; however, glucose was not. Their atherogenic index was also significantly improved (p<0.05), although no significant differences of HIDL-cholesterol and LDL-cholesterol were detected. The elevated levels of glucose, AST, ALT, and v-GTP in alcoholics may not always indicate increased alcohol consumption, but may also suggest the existence of some metabolic syndrome with its subsequent deleterious consequences. Especially the effect of alcohol consumption on glucose level deserves observation. Larger, long-term, controlled clinical trials are needed to evaluate the effect of alcohol consumption.
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KEYWORD
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Alcoholics, moderate drinkers, normal non-drinkers, blood components, glucose
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